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M Pharm Pharmacology Syllabus Semester-Wise, Research Methodology

M Pharm Pharmacology Syllabus gives advanced knowledge of drug actions, lab techniques, and clinical research. The M Pharm Pharmacology Syllabus includes semester-wise subjects, practicals, research methods, and PCI guidelines to prepare students for pharma, hospital, and research roles.

authorImageShruti Kumari30 Oct, 2025
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M Pharm Pharmacology Syllabus

M Pharm Pharmacology Syllabus is made to give students deeper knowledge about how medicines work in the body. It also teaches different lab methods and modern research in pharmacology.

This syllabus helps students understand how drugs act at the cell level, in different organs, and in the whole body. It prepares them for work in research, hospital studies, and medicine development. Explained here is the subject list, topics for each semester, research methods, and practical work. It follows the rules of PCI and other health authorities in 2025.

M Pharm Pharmacology Syllabus Overview

M Pharm Pharmacology Syllabus focuses on both theoretical and practical aspects of pharmacology. It includes modern analytical techniques, preclinical and clinical pharmacology, molecular pharmacology, toxicology, drug discovery, and pharmacovigilance. The syllabus ensures students gain expertise in:

  • Drug mechanism at cellular and molecular levels.

  • Preclinical and clinical evaluation of drugs.

  • Use of advanced instruments like HPLC, GC, NMR, and mass spectrometry.

  • Research methods and data interpretation in pharmacology.

This curriculum also provides exposure to regulatory guidelines such as CPCSEA, OECD, ICH, and USFDA.

M Pharm Pharmacology Syllabus (Semester Wise)

Provided here is the detailed M Pharm Pharmacology Syllabus. Candidates should refer to the table for more information:

Detailed M Pharm Pharmacology Syllabus
Semester Course Code & Subject Type Hours Main Topics Sub-Topics / Detailed Syllabus
I MPL 101T – Modern Pharmaceutical Analytical Techniques Theory 60 Spectroscopy UV-Visible, IR, Fluorescence, Flame Emission, Atomic Absorption, NMR (1H, 13C, FT-NMR), Mass Spectrometry (MALDI, APCI, ESI)
Chromatography TLC, HPTLC, HPLC, UHPLC, Column, Gel, Affinity, Ion Exchange
Electrophoresis Paper, Gel, Capillary, Isoelectric Focusing (IEF)
Crystallography & Thermal X-ray Crystallography, DSC, TGA, DTA, DDTA
Potentiometry & Electrochemical Potentiometry, Conductometry, Voltammetry
I MPL 105P – Pharmacological Practical I Practical 60 Analytical & Instrumentation UV-Vis Estimation, HPLC, GC, Fluorimetry, Flame Photometry
Animal Handling Drug Administration, Blood Sampling, Anesthesia, Euthanasia
Pharmacological Experiments CNS, Analgesic, Anti-inflammatory, Mydriatic, Diuretic, Anti-ulcer, OGTT
Molecular Techniques DNA/RNA Isolation, Protein Estimation, PCR, Western Blotting
Cellular Assays Cell Viability, Apoptosis, Enzyme Assays, Pharmacokinetics
I MPL 102T – Advanced Pharmacology I Theory 60 General Pharmacology Pharmacokinetics, Pharmacodynamics, Receptors
Neurotransmission Autonomic, CNS, NANC neurotransmitters
Systemic Pharmacology ANS, CNS, Cardiovascular, Autacoids (Histamine, Serotonin, Kinins, Prostaglandins, Opioids)
I MPL 103T – Pharmacological & Toxicological Screening Methods I Theory 60 Animal Models Laboratory animals, Transgenic models, CPCSEA Guidelines
Preclinical Screening CNS, ANS, Respiratory, Reproductive, Analgesics, Anti-inflammatory, GI, Cardiovascular, Metabolic, Anticancer, Hepatoprotective, Immunomodulators
Immunoassays Digoxin, Insulin assays
Alternate Methods In vitro assays, Computer simulations
I MPL 104T – Cellular & Molecular Pharmacology Theory 60 Cell Biology Organelles, Genome, Gene Expression, Apoptosis, Necrosis, Autophagy
Cell Signaling GPCR, Tyrosine Kinase, Ion Channels, Secondary Messengers, MAPK, JAK/STAT
Genomic & Proteomic Tools PCR, Electrophoresis, ELISA, Western Blot, Microarray, Recombinant DNA, Gene Therapy
Pharmacogenomics Personalized medicine, Drug response variations
Cell Culture Primary culture, Cell lines, Biosimilars
II MPL 201T – Advanced Pharmacology II Theory 60 Endocrine Pharmacology Thyroid, Hypoglycemic drugs, Corticosteroids, Contraceptives
Chemotherapy Antimicrobials (Anti-bacterial, Anti-fungal, Anti-viral, Anti-TB), Anti-protozoal, Anti-helminthic, Anticancer
Immunopharmacology Inflammation, Asthma, COPD, Immunosuppressants & Immunostimulants
GIT Pharmacology Antiulcer, Prokinetics, Antiemetics, Anti-diarrheals, Chronopharmacology
Free Radical Pharmacology Antioxidants, Alzheimer’s, Parkinson’s, Cancer, Diabetes
II MPL 202T – Pharmacological & Toxicological Screening Methods II Theory 60 Toxicology Acute, Sub-acute, Chronic, Reproductive, Genotoxicity, Carcinogenicity
Safety Pharmacology Tier 1 & 2 studies, IND enabling studies
Regulatory Guidelines OECD, ICH, EPA, Schedule Y, GLP Principles
II MPL 203T – Principles of Drug Discovery Theory 60 Drug Discovery Process Target Identification, Validation, Lead Optimization
Tools & Techniques Genomics, Proteomics, Bioinformatics, Combinatorial Chemistry, High-Throughput Screening, Virtual Screening, Molecular Docking, QSAR, Prodrug Design
II MPL 204T – Clinical Research & Pharmacovigilance Theory 60 Regulatory Guidelines ICH-GCP, ICMR, Schedule Y
Clinical Trial Design RCT, Non-RCT, Cohort, Case-Control, Cross-sectional
Documentation & Monitoring Protocol, CRF, Investigator Brochure, Safety Monitoring
Pharmacovigilance ADR Reporting, Tools & Software (VigiFlow, Argus, Aris G), Pharmacoepidemiology, Pharmacoeconomics
II MPL 205P – Pharmacological Practical II Practical 60 Dose-Response & Bioassays DRC, PA2 Estimation, Bioassays (Matching, Interpolation, Bracketing, Multi-point)
Isolated Organ & Animal Studies Isolated Heart, Rat Studies (BP, ECG, Drug Absorption)
Toxicity & Mutagenicity Acute, Repeated Dose, Bone-Marrow Test
Clinical & In-silico Clinical Trial Protocol, ADR Monitoring, Docking, Pharmacophore & QSAR Studies, ADR Reporting

Semester-Wise M Pharm Pharmacology Syllabus

The semester-wise M Pharm Pharmacology syllabus is structured to gradually build knowledge from fundamental concepts to advanced research techniques. Below is a detailed breakdown:

Semester I

Here is subjectwise syllabus for Semester I:

Subject Topics Covered Hours
Modern Pharmaceutical Analytical Techniques (MPL 101T) UV-Visible spectroscopy, IR spectroscopy, NMR, Mass Spectrometry, Chromatography (HPLC, GC, TLC), Electrophoresis, X-ray Crystallography, Thermal Techniques, Potentiometry 60
Advanced Pharmacology I (MPL 102T) General Pharmacology, Pharmacokinetics, Pharmacodynamics, Neurotransmission, Systemic Pharmacology (Autonomic, CNS, Cardiovascular, Autocoids) 60
Pharmacological and Toxicological Screening Methods I (MPL 103T) Laboratory animals, Bioassays, Preclinical screening (CNS, Respiratory, Cardiovascular, Reproductive, Gastrointestinal systems), Immunoassays 60
Cellular and Molecular Pharmacology (MPL 104T) Cell biology, Signaling pathways, Genomic and proteomic tools, Pharmacogenomics, Cell culture techniques, Biosimilars 60
Pharmacological Practical I (MPL 105P) UV-Vis estimation, HPLC and GC experiments, Fluorimetry, Flame photometry, Animal handling and drug evaluation, DNA/RNA/protein estimation, Enzyme-based assays, Cell viability assays 60

Semester II

Here is subjectwise syllabus for Semester II:

Subject Topics Covered Hours
Advanced Pharmacology II (MPL 201T) Endocrine pharmacology, Chemotherapy (antimicrobial, anticancer, antiviral), GIT pharmacology, Free radical pharmacology, Recent advances in Alzheimer’s, Parkinson’s, Diabetes 60
Pharmacological and Toxicological Screening Methods II (MPL 202T) Toxicology types, OECD and ICH guidelines, Acute, sub-acute, chronic studies, Reproductive toxicology, Genotoxicity, Carcinogenicity, IND enabling studies, Safety pharmacology, Toxicokinetics 60
Principles of Drug Discovery (MPL 203T) Drug discovery process, Target identification and validation, Lead identification, Rational drug design, Molecular docking, QSAR, Prodrug design, Role of bioinformatics, Genomics and proteomics 60
Clinical Research and Pharmacovigilance (MPL 204T) Regulatory perspectives, Clinical trial types, Documentation, ADR detection and reporting, Pharmacovigilance methods, Pharmacoepidemiology, Safety pharmacology 60
Pharmacological Practical II (MPL 205P) Bioassays, PA2 value estimation, Drug effects on isolated tissues and organs, Rat ECG and BP recording, Toxicity studies, Clinical trial protocols, In-silico studies, ADR reporting 60

Research Methodology in Pharmacology

Research methodology is a key component of the M Pharm Pharmacology syllabus. Students learn to:

  • Design experiments and clinical trials following ethical and regulatory standards.

  • Use in vitro and in vivo models for preclinical screening.

  • Apply statistical tools for data analysis.

  • Perform in-silico docking and pharmacophore-based drug screening.

  • Evaluate ADME (absorption, distribution, metabolism, excretion) and pharmacokinetic profiles.

 

M Pharm Pharmacology Syllabus FAQs

What is the focus of the M Pharm Pharmacology syllabus?

It emphasizes advanced drug mechanisms, experimental techniques, and modern pharmacological research for clinical and pharmaceutical applications.

How is the syllabus structured across semesters?

Semester I covers fundamental concepts and practicals, while Semester II focuses on advanced pharmacology, drug discovery, clinical research, and pharmacovigilance.

Are practical components included in the syllabus?

Yes, practicals include analytical techniques, animal studies, cellular assays, bioassays, toxicity testing, and in-silico studies.

Does the syllabus cover regulatory guidelines?

Yes, it includes CPCSEA, OECD, ICH, USFDA, GLP, and Schedule Y for preclinical and clinical studies.

Is research methodology part of the curriculum?

Yes, it teaches experimental design, preclinical screening, statistical analysis, in-silico studies, and pharmacokinetic evaluations.
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