What is the purpose of the pentose phosphate pathway?
Pentose Phosphate Pathway
• It is also Known by other names like oxidative phosphate pathway, hexose monophosphate shunt (HMP), Warburg, Limpam-Dickens cycle and phosphogluconate shunt.
• The pathway is an alternate mechanism of glucose oxidation or respiration which was first studied by Warburg and Dickens.
• It occurs inside the cytoplasm and plastids. Plastids PPP predominates over cytosolic PPP.
• PPP is favoured by the presence of NADP is in the cytoplasm.
• For energy six molecules of glucose only one is completely oxidized while the other five are regenerated. Oxidation of glucose is linked to the formation of NADPH. CO2 is liberated.
i) PPP is an alternate pathway of aerobic respiration which occurs in the cytoplasm.
ii) It produces NADPH for various biosynthetic reactions including fatty acid and steroid synthesis.
iii) The pathway produces a number of tetroses and pentoses for the synthesis of nucleosides, nucleotides, nucleic acids, lignin, anthocyanins, indol 3-acetic acid and a number of other compounds.
iv) It helps in overcoming oxidative stress in red blood cells by maintaining reduced glutathione.
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