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Difference Between Karyokinesis and Cytokinesis with Stages

Difference Between Karyokinesis And Cytokinesis is that karyokinesis is the process of dividing the nucleus, whereas cytokinesis is the division of the cytoplasm.
authorImageKrati Saraswat10 Jun, 2025
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Difference Between Karyokinesis and Cytokinesis

Difference Between Karyokinesis and Cytokinesis Overview

Karyokinesis is the division of the nucleus during cell division, in which replicated chromosomes are distributed among two daughter nuclei.  Cytokinesis, on the other hand, is the division of the cell's cytoplasm that occurs after the chromosomes are evenly distributed between the daughter cells. Furrowing is the process by which cytoplasm divides. Both karyokinesis and cytokinesis are necessary processes for cell division. Karyokinesis targets the nucleus, the cellular organelle that contains DNA, the genetic material that determines cell characteristics. It involves the division of the nucleus into two distinct nuclei. Meanwhile, cytokinesis focuses on dividing the cytoplasm, a cellular organelle that contains essential proteins and molecules required for cellular function. This process results in the formation of two separate cytoplasms. Both karyokinesis and cytokinesis are imperative for complete cell division. While karyokinesis facilitates nucleus division, cytokinesis ensures the division of the cytoplasm. Both processes are integral components of mitosis, the cellular division process in animals. The detailed difference between karyokinesis and cytokinesis is provided in this article.

Difference Between Karyokinesis and Cytokinesis

Karyokinesis and Cytokinesis are two stages in cell division. Karyokinesis, which occurs during the M phase of the cell cycle, involves nucleus division, ensuring an even distribution of genetic material, and the separation of daughter nuclei from a daughter chromosome.  Regardless of cytokinesis, this first step is very important for genetic integrity. Cytokinesis, which occurs in the M phase after karyokinesis, is critical for mitosis completion.  Cytoplasm division occurs when cellular organelles and cytoplasm are divided between the two emerging daughter cells.  Cytokinesis is dependent on previous karyokinesis to proceed, ensuring successful cell division and the production of two genetically identical daughter cells. The table below shows the detailed difference between karyokinesis and cytokinesis:
Difference Between Karyokinesis And Cytokinesis
Category Karyokinesis Cytokinesis
Definition Refers to cell division during mitosis, ensuring genetic material separation. Marks cell division conclusion, finalizing reproductive process after meiosis.
Order Initiates cell division as primary stage. Follows karyokinesis, dividing cytoplasm as subsequent stage.
Significance Vital for cell regeneration and renewal post-division. Indispensable for completing cell division, driven by daughter cell nuclei.
Procedure Equally distributes genetic material between daughter cells. Equitably distributes cellular substances and cytoplasm.
Function Orchestrates chromosomal movement and spindle formation. Includes processes like cell plate development and embryonic cleavage.
Complexity Involves complex and sequential genetic material division. Represents relatively straightforward process facilitating cell division.
Varieties Does not exhibit distinct types. It can be asymmetrical or symmetric, depending on how the cellular components are distributed.

Karyokinesis

Karyokinesis, the initial phase of mitosis, comprises several stages: Prophase, Prometaphase, Metaphase, Anaphase, and Telophase. The term "karyokinesis" originates from the Greek words "karyon," meaning nucleus, and "kinesis," meaning division, denoting the process of nucleus division into two daughter cells.
  Prophase: After replication in the S phase, chromosomes condense further, allowing them to be identified as distinct structures under a microscope. Centrioles replicate simultaneously, with daughter centrioles migrating to opposite poles of the cell to form the mitotic spindle, which is primarily made up of microtubule proteins.
  Prometaphase: Prometaphase occurs when chromosomes, made up of paired sister chromatids connected at the centromere, migrate towards the cell's center. Meanwhile, centrioles continue to assemble the mitotic spindle, which functions as a network of fine fibers.
  Metaphase: In humans, all 46 chromosomes align sequentially along the metaphase plate, a plane that runs through the center of the cell and is perpendicular to the poles. This alignment ensures that one sister chromatid from each pair is located on each side of the plate.
  Anaphase: Spindle fibers exert significant force, pulling chromatids towards the cell's opposite poles. A cleavage furrow appears at the same time, indicating the start of cytokinesis.  At the end of Anaphase, each set of 46 chromatids forms clusters at opposing ends of the cell.
  Telophase: Telophase marks the final stage, where the replicated and separated genetic material is enclosed within individual nuclear envelopes. Additionally, the genetic material decondenses. Telophase essentially mirrors prophase in reverse. Early cytokinesis commences during the telophase.

Cytokinesis

After mitosis, the next stage is known as cytokinesis, which is the second and final phase of cell division. The term "cyto" refers to the "cytoplasm," whereas "kinesis" means "division," indicating the equitable division of cytoplasm into two daughter cells. It is important to note that cytokinesis differs between plant and animal cells. animal cells. The stages of cytokinesis are as follows:
  Step 1: The first phase focuses on determining the location of the cleavage furrow, where actin filaments will cause constriction around the cell. The spindle separates this region and ensures that chromosomes are evenly distributed between the two nuclei. The spindle organises within the cell, interacting with the nuclei and plasma membrane. Furthermore, the spindle's astral microtubules connect to the cell membrane, directing the arrangement of actin fibers toward the upcoming cleavage furrow.
  Stage 2: After determining the location of the cleavage furrow, actin filaments cluster. Several proteins, including myosin, are drawn to this location, allowing actin fibers to contract as the contractile ring forms.
  Stage 3: Myosin, a mechanical protein known as a molecular motor, is essential during this stage. While myosin is required for muscle contraction, it contracts the contractile ring with the help of ATP, causing the cleavage furrow to deepen. This leads to cell constriction at the center, ultimately resulting in the formation of two daughter cells.
  Stage 4: The final step in cytokinesis is the definitive rupture of the cell membrane as it reaches its narrowest point. The membrane quickly ruptures at the designated site, separating into two distinct and identical daughter cells, each with the ability to function independently.
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[wp-faq-schema title="Difference Between Karyokinesis and Cytokinesis FAQs" accordio=1]

Difference Between Karyokinesis and Cytokinesis FAQs

What is the difference between karyokinesis and cytokinesis?

Cytokinesis is about dividing the cytoplasm of a cell, while karyokinesis is all about splitting the nucleus. During cytokinesis, the cytoplasm and other bits inside the cell are divided and shared between new cells.

Why is karyokinesis and cytokinesis important?

Karyokinesis is crucial because it helps in making new cells and fixing old ones. Meanwhile, cytokinesis is necessary for splitting the cell into two new ones. Both processes ensure everything gets divided up evenly so that each new cell has what it needs to function.

What's the biggest difference between mitosis and cytokinesis?

Mitosis is when a cell splits into two, while cytokinesis is just one part of that process where the cell's insides are divided. So, mitosis is like the big picture of cell division, and cytokinesis is just one step in that big picture.

Which phase of the cell cycle is longest?

The longest part is known as interphase. This is when the cell divides and replicates its DNA. Following interphase, the cell is ready for mitosis, in which its chromosomes align and split to form new cells.

What are the four steps of karyokinesis?

Karyokinesis, also known as mitosis, has four main stages: prophase, metaphase, anaphase, and telophase. Each stage has its own job in splitting up the cell's nucleus and making new cells.
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