NIPER JEE Syllabus 2025, Subject and Section Wise Detailed Syllabus

Section

Subjects

No. of Questions

A

General English, Aptitude, Reasoning, and General Knowledge.

40

B

Syllabi of B. Pharm. and PG degrees (MSc.)

160

Section

Subjects

No. of Questions

A

Chemical Sciences, Biological Sciences, Pharmaceutical Sciences and Medical Devices

170

B

General Aptitude, Reasoning, General English

30

Subject

Topics

Natural Products

• Secondary metabolites

• Phytochemistry

• Methods of extraction, isolation, and characterization of natural products

• Primary metabolites

• Marine natural products

• Plant growth regulators

• Spectroscopy

• Dietary antioxidants

• Biosynthetic pathways

• Important therapeutic classes

Stereochemistry

• Pharmacology and toxicology

• Evaluation of formulation, principles, and methods of release control in oral formulations

• Bioavailability, bioequivalence studies

• Compartmental modelling

• Packaging

• Dosage forms

• Pharmaceutics and formulation (Pharmaceutical Technology)

•  Pharmacokinetics

•  Pharmacodynamics

•  The pharmacological effect, desired, undesired, toxic, and adverse effects

•  Bioavailability, bioequivalence, and various factors of ADME

•  Drug metabolism

•  Drug interactions, agonist, antagonist, protein binding, drug distribution, distribution volume, excretion pathways

•  Pharmacological screening

•  Mechanism of drug action

•  Drug-receptor interaction

•  Detailed study of CNS pharmacology Transdermal drug delivery systems

•  Diseases

•  Chemotherapy and pathophysiology

•  Bioassay methods

•  Drug delivery systems (DDS)

•  Carriers in DDS

•  Biological sources of important classes of natural products

•  Parenteral

•  Drug targeting

• Complexation

• Solubilisation

• Dosage form development- stages, implications of dosage form

• Viscosity measurements

• Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities

• (TDDS)

•  Fischer, sawhorse and Newman projection formulas

•  Standardization of natural products

•  Various adrenergic, cholinergic and other receptors

Pharmaceutical analysis

• Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf-life determination, thermal stability, formulation stability

• Various analytical techniques

• Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.

• Solubility

• Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.

• Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc. 

• Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns

• Osmolality, osmolality, osmotic pressure, conductivity, Preservatives, Media for bioassay.

• Spectroscopic methods

• Electrophoresis

• UV-Visible

• Particle sizing

•  Chromatography- detailed QA and QC: GLP, TQM, ISO system

•  Preformulation, cyclodextrin inclusion compounds

•  Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.

•  Dosage forms, Stages of dosage form development

• NMR

• XRD

• IR

• Fluorimetry

•  HPLC

•  IR

•  GC

•  LCMS

•  Mass

•  NMR Peaks

Biotechnology and biochemistry

• Pharmaceutical technology

• Classification of enzymes and the mechanism of their function of action

•   Immunoassays, Protein

•  RNA synthesis

•  DNA synthesis

•  rDNA technology

• Gene expression

• Genetic Engineering

•  Blotting techniques(Western, Southern)

•  Gel electrophoresis

•  Gene cloning

Gene expression

• Mutation

• Replication

• Transcription

• Translation

• Recombination

•  Bacteriophages

Cloning

• Fermentation

• Methods, isolation of nucleic acids, enzymes in cloning

Chemistry

• Basic organic chemistry and biochemistry Stereochemistry

• Osazone test

• Mutarotation

• Medicinal chemistry and Bulk Drugs

• Keto-enol tautomerism

• IUPAC nomenclature

• Introduction to thermal methods of analysis

• Introduction to Redox reactions

• Racemic mixture

• R and S nomenclature

• Reactions like Cannizarro’s reaction

• Pericyclic reactions

• Ester hydrolysis

• Huckel’s rule reaction mechanisms-

• E and Z isomerism

• Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen

• Chromatography

• Carbohydrates classification

• Aromaticity

• Imine-enamine

• Hybridization

• Amino acids proteins

• Type of stereoisomer

• Basic methods of synthesis of various organic compounds

• Named reactions

• Various Heterocycles, Heterocycle synthesis, reactions

• Tautomerism

• Spectroscopy

• Resolution methods

• Reaction kinetics, first second third and pseudo-first-order reactions, radiolabeling for determination of mechanism.

Pharmacology

• Bioavailability, bioequivalence, various factors of ADME

• Study of the basis of threshold areas of work in NIPER in the pharmacology dept. Mentioned in the brochure.

• Detailed study of CNS pharmacology especially opioid receptors

• Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.

• Drug metabolism: various pathways and other details.

• Drug interactions, agonist, antagonist, Mechanism of drug action, drug-receptor interaction.

• Various adrenergic, cholinergic and other receptors

• Partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.

• Bioassay methods, various requirements. Brief knowledge of the statistical tests.

• Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.

• Diseases: a study of the pharmacology of the diseases and drugs used with the mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodulation.

Phytochemistry

• Methods of extraction, isolation, and characterization of natural products.

• Various separation techniques used for the isolation of natural products.

• Important therapeutic classes: anti-diabetics, hepato-protectives, immunomodulators, nutraceuticals, natural products for gynaecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.

• Dietary antioxidants, Marine natural products, plant growth regulators.

• Fischer projection formulas.

• Biological sources of important classes of natural products. (Selected ones only)

• Standardization of natural products, analytical pharmacognosy.

• Difference between natural products and pharmacognosy

• Some knowledge about types and preparation of ayurvedic formulations like asava, arista etc.

• Biosynthetic pathways.

• Primary metabolites, their examples

• Secondary metabolites, various classes of secondary metabolites (Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, etc.).