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Schimdt Reaction

About Schimdt Reaction

This is the reaction between a carbonyl compound and hydrazoic acid in the presence of a strong acid concentrated sulphuric acid. Aldehydes give a mixture of cyanide and formyl derivatives of primary amines, whereas ketones give amides. This reaction closely related to Hofmann and Curtius reaction, of all which involves formation of isocyanate intermediate through the migration of group from carbon to nitrogen. the rearrangement closely resembles the Beckmann rearrangement.

Schimdt Reaction

Schimdt Reaction

It has been shown to be intramolecular, and Smith (1948) has proposed the following mechanism, which is an example of the 1, 2-shift (from carbon to nitrogen); for ketones :


Reaction Mechanism of Schimdt Reaction

In ketones, if the two groups are not identical, then two geometrical isomers of (I) are possible. It is also reasonable to suppose that the anti group (to the diazonium nitrogen) is the group that migrates. In this way it is possible to explain how steric factors may influence the isomer ratio of amides formed:For aldehydes and so the reaction maybe formulated.

mechanism of Schimdt Reaction


List of Name Reaction of Organic Chemistry consist of detail Reaction Mechanism of all name reactions of Organic Chemistry.




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