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Wolf Kishner Reduction

Introducation to Wolf Kishner Reduction

About Wolf Kishner Reduction

This is a selective reduction it can reducse only carbonyl compound unable to reduce the OH group . When a ketone or an aldehyde is heated in a basic solution of hydrazine, the carbonyl group is converted to a methylene group this process is called Deoxygenation because an oxygen is removed from the reactant. The reaction is known as the Wolf-Kishner Reduction.

Initially the ketone reacts with hydrazine to form a hydrazone. Hydroxide ion and heat differentiate the Wolff-Kishner Reduction from ordinary hydrazone formation. After the hydrazone is formed, OH removes a proton from the NH2 group. Heat is required because these protons are not easily removed. Resonance places some of the negative charge on carbon, which abstracts a proton from water. The last two steps are repeated to from the deoxygenated product and N2 gas

Mechanism for Wolff-Kishner

Wolf Kishner Reduction

List of Name Reaction of Organic Chemistry consist of detail Reaction Mechanism of all name reactions of Organic Chemistry.

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